Post Doctoral Research Scientist - Bioinformatics (m/f/d)

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Full-timeTätigkeitsfeld: Wissenschaft und ForschungBeschäftigungsumfang: Vollzeit

Company Description

The Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart (Director Prof. Dr. M. Schwab) is operated by the Robert Bosch Foundation. Since its foundation in 1973, the institute has emerged as Germany's largest and most renowned scientific research unit in the field of clinical pharmacology. Main research activities concentrate on the influence of genetic and non-genetic factors on variability of drug efficacy and their contributions to disease development.For a research project investigating cancer therapy and tumor cell biology of renal cell carcinoma. The project will focus on the bioinformatic analysis of transcriptomics data, particularly spatial transcriptomics combined with single cell datasets, as well as spatial multiplex immunofluorescence data. It offers the opportunity to develop novel bioinformatics solutions. Functional studies using 3D tumour cell models complement the data sets in order to enhance our understanding of tumour biology in renal cell carcinoma. The project will be closely linked to clinical aspects of cancer research.

Job Description

Bioinformatic analysis of multi-omics data with focus on single-cell and spatial transcriptomics RNA sequencing data to elucidate the tumor microenvironment and its influence on cancer progression and metastasis in renal cell carcinomaIntegrating multi-omics data sets (e.g. genomics, metabolomics) of primary tumors and metastasis through innovative bioinformatics analysis applicable to high-dimensional dataIntegrated analysis of clinical phenotypes and -omics data using biostatistics and bioinformaticsApplication of a broad spectrum of established tools and development of new computational solutions with focus on single-cell and spatial transcriptomics RNA seq and data integrationEnthusiasm to present scientific results at international conferences and writing papers for high-quality publications to ensure greatest possible success in your career track

Qualifications

Doctoral degree (PhD) in bioinformatics, applied bioinformatics or a related disciplineExperience and strong background in the analysis of spatial transcriptomics and single-cell RNA sequencing data, as well as multi-omics datasets (e.g. proteomics, transcriptomics, genomics), including data interpretation.Strong interest in life science applications with focus on oncology and personalized medicineStrong programming skills in R and in PythonSolid background in cancer biologyKnowledge in biostatistics would be beneficialExcellent English written and oral communication skills, as well as expertise in preparation of scientific manuscripts.

Additional Information

We offer:The opportunity to work in an interactive team of bioinformaticians, clinicians and biologists.State-of-the-art equipment and technologies for a wide range of different applications (genomics, transcriptomics, metabolomics) and expert knowledge within the different core facilities (e.g. core facility "Biostatistics/Bioinformatics, Pharmacometrics and Digital Science") at the instituteThe opportunity to communicate scientific results at international conferences and to participate in workshopsAn initial contract for 3 years and flexible starting date (earliest starting date as of now)

For further information please contact Prof. Dr. Matthias Schwab (phone or Dr. Elke Schaeffeler (phone Sind Sie bereit für eine neue Herausforderung? Dann bewerben Sie sich jetzt über unser Online-Karriereportal .

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